Inhaled Carbon Monoxide Confers Antiinflammatory Effects against Ventilator-induced Lung Injury
نویسندگان
چکیده
منابع مشابه
Carbon monoxide protects against ventilator-induced lung injury via PPAR-gamma and inhibition of Egr-1.
RATIONALE Ventilator-induced lung injury (VILI) leads to an unacceptably high mortality. In this regard, the antiinflammatory properties of inhaled carbon monoxide (CO) may provide a therapeutic option. OBJECTIVES This study explores the mechanisms of CO-dependent protection in a mouse model of VILI. METHODS Mice were ventilated (12 ml/kg, 1-8 h) with air in the absence or presence of CO (2...
متن کاملInhaled carbon monoxide and hyperoxic lung injury in rats.
Because carbon monoxide (CO) has been proposed to have anti-inflammatory properties, we sought protective effects of CO in pulmonary O(2) toxicity, which leads rapidly to lung inflammation and respiratory failure. Based on published studies, we hypothesized that CO protects the lung against O(2) by selectively increasing expression of antioxidant enzymes, thereby decreasing oxidative injury and...
متن کاملEffects of inhaled carbon monoxide on acute lung injury in mice.
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are major causes of morbidity and mortality in the intensive care unit, but despite continuing research few effective therapies have been identified. In recent years, inhaled carbon monoxide (CO) has been reported to have cytoprotective effects in several animal models of tissue injury. We therefore evaluated the effects of ...
متن کاملTRANSLATIONAL PHYSIOLOGY Effects of inhaled carbon monoxide on acute lung injury in mice
Subhamay Ghosh, Michael R. Wilson, Sharmila Choudhury, Hirotoshi Yamamoto, Michael E. Goddard, Boglarka Falusi, Nandor Marczin, and Masao Takata Department of Anaesthetics and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London; and Department of Cardiothoracic Surgery and Anaesthetics, Imperial College London, and Heart Science Centre, Harefie...
متن کاملVentilator-induced lung injury.
From the Keenan Research Center, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, and the Department of Medicine and Interdepartmental Division of Critical Care Medicine, University of Toronto — both in Toronto (A.S.S.); and Dipartimento di Anestesia e Medicina degli Stati Critici, Ospedale S. Giovanni Battista Molinette, Università di Torino, Turin, Italy (V.M.R.). Address reprint requ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Respiratory and Critical Care Medicine
سال: 2004
ISSN: 1073-449X,1535-4970
DOI: 10.1164/rccm.200401-023oc